Public Service Must Begin at Home : The Lawyer as Civics Teacher in Everyday Practice

Fifty years ago, the leading national representatives of the American legal profession, the American Bar Association (ABA), and the Association of American Law Schools (AALS), issued a joint report (the Report) on the nature of lawyers\u27 professional responsibility in the context of the adversary system. Principally authored by legal philosopher Lon Fuller, who co-chaired the joint conference that issued it, the Report\u27s premise was that the legal profession\u27s inherited traditions provided only indirect guidance to lawyers in light of their changing roles, and that a true sense of professional responsibility must derive from an understanding of the special services that the legal profession renders to society and the services it might render if its full capacities were realized. A decade later, the Report was quoted throughout the footnotes to the Preamble and Ethical Considerations of the ABA Code of Professional Responsibility, suggesting that the Report captured or influenced understandings that continued at least through the early 1970s. The Report\u27s account of Greenhill v. Greenhill, the 1836 case that Thomas Talfourd argued, is too abbreviated to capture the extent of the injustice he helped achieve. In 1835, six years after her marriage, and while caring for three infant daughters, Mrs. Greenhill learned that her husband, whom she believed to be off yachting, had in fact been living for more than a year with another woman whom he passed off as his wife. When Mrs. Greenhill brought divorce proceedings, Mr. Greenhill retaliated by demanding that she relinquish the children. Custody proceedings followed. Despite Mr. Greenhill\u27s refusal to end his adulterous relationship and despite Mrs. Greenhill\u27s undeniable fitness as a parent, Mr. Greenhill had the superior legal right under precedents that regarded children as the husband\u27s chattel. Mr. Greenhill demanded that the children be delivered to his mother, with whom he had formerly been estranged and who had until then refused to see her grandchildren. Further, he sought to prevent his wife from seeing the children, as was his legal right. When Mrs. Greenhill refused to comply with a court order to deliver up the children, her husband sought her imprisonment for contempt of court. Mrs. Greenhill offered to live anywhere and to make any arrangement for Mr. Greenhill to visit the children, but Mr. Greenhill, spurred on by his mother, refused even at the judge\u27s urging to reach an accommodation. This was the matter in which Talfourd successfully advocated the husband\u27s custody claim. As a contemporary put it: Talfourd had been compelled to support that as an advocate, which as a man, possessed of the same generous sympathies as his fellow men, he must have felt to be iniquitous and absurd. Talfourd\u27s work to reform the child custody law exemplifies a conception of the citizen-lawyer that has prevailed since our country\u27s founding. The conception of the lawyer as civics teacher directly addresses the lawyer\u27s role as client counselor in the daily private practice of law, regardless of whether the matter relates to a transaction or to litigation. This Essay begins in Part I by sketching the concept of the lawyer as civics teacher. Part II offers two reasons why lawyers should make a self-conscious effort to teach civics well and shows how this conception is rooted in Fuller\u27s Report as well as in writings that both predate and postdate it. Finally, Part III places the conception in the context of contemporary professional and academic discussion of four subjects: the lawyer\u27s duty to serve the public, the lawyer\u27s role in a democracy, the lawyer\u27s counseling function, and the lawyer\u27s dealings with professional colleagues

Contextualizing Professional Responsibility: A New Curriculum for a New Century

Daly et al assert that professional responsibility has matured as a subject matter to the point where a new genre of courses should join the pervasive method and the traditional survey course. The new age of professaional responsibility will reflect intellectual maturity through the introduction of contextual course that are designed to nurture the development of reflective ethical judgment

Investigating Perceptual Congruence Between Data and Display Dimensions in Sonification

The relationships between sounds and their perceived meaning and connotations are complex, making auditory perception an important factor to consider when designing sonification systems. Listeners often have a mental model of how a data variable should sound during sonification and this model is not considered in most data:sound mappings. This can lead to mappings that are difficult to use and can cause confusion. To investigate this issue, we conducted a magnitude estimation experiment to map how roughness, noise and pitch relate to the perceived magnitude of stress, error and danger. These parameters were chosen due to previous findings which suggest perceptual congruency between these auditory sensations and conceptual variables. Results from this experiment show that polarity and scaling preference are dependent on the data:sound mapping. This work provides polarity and scaling values that may be directly utilised by sonification designers to improve auditory displays in areas such as accessible and mobile computing, process-monitoring and biofeedback

Legume based plant mixtures for delivery of multiple ecosystem services: An overview of benefits

As costs for mineral fertilizers rise, legume-based leys are recognised as a potential alternative nitrogen source for crops. Here we demonstrate that including species-rich legume-based leys in the rotation helps to maximize synergies between agricultural productivity and other ecosystem services. By using functionally diverse plant species mixtures these services can be optimised and fine-tuned to regional and farm-specific needs. Field experiments run over three years at multiple locations showed that the stability of ley performance was greater in multi-species mixtures than in legume monocultures. In addition, mixing different legume species in the ley helps to suppress both early and late weeds. Further, combining complementary phenologies of different legume species extended forage availability for key pollinator species. Finally, widening the range of legume species increases opportunities to build short term leys into rotations on conventional farms via cover cropping or undersowing

Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme

Polypharmacy increasingly has become a topic of public health concern, particularly as the U.S. population ages. Drug labels often contain insufficient information to enable the clinician to safely use multiple drugs. Because many of the drugs are bio-transformed by cytochrome P450 (CYP) enzymes, inhibition of CYP activity has long been associated with potentially adverse health effects. In an attempt to reduce the uncertainty pertaining to CYP-mediated drug-drug/chemical interactions, an interagency collaborative group developed a consensus approach to prioritizing information concerning CYP inhibition. The consensus involved computational molecular docking, spectral data-activity relationship (SDAR), and structure-activity relationship (SAR) models that addressed the clinical potency of CYP inhibition. The models were built upon chemicals that were categorized as either potent or weak inhibitors of the CYP3A4 isozyme. The categorization was carried out using information from clinical trials because currently available in vitro high-throughput screening data were not fully representative of the in vivo potency of inhibition. During categorization it was found that compounds, which break the Lipinski rule of five by molecular weight, were about twice more likely to be inhibitors of CYP3A4 compared to those, which obey the rule. Similarly, among inhibitors that break the rule, potent inhibitors were 2–3 times more frequent. The molecular docking classification relied on logistic regression, by which the docking scores from different docking algorithms, CYP3A4 three-dimensional structures, and binding sites on them were combined in a unified probabilistic model. The SDAR models employed a multiple linear regression approach applied to binned 1D 13C-NMR and 1D 15N-NMR spectral descriptors. Structure-based and physical-chemical descriptors were used as the basis for developing SAR models by the decision forest method. Thirty-three potent inhibitors and 88 weak inhibitors of CYP3A4 were used to train the models. Using these models, a synthetic majority rules consensus classifier was implemented, while the confidence of estimation was assigned following the percent agreement strategy. The classifier was applied to a testing set of 120 inhibitors not included in the development of the models. Five compounds of the test set, including known strong inhibitors dalfopristin and tioconazole, were classified as probable potent inhibitors of CYP3A4. Other known strong inhibitors, such as lopinavir, oltipraz, quercetin, raloxifene, and troglitazone, were among 18 compounds classified as plausible potent inhibitors of CYP3A4. The consensus estimation of inhibition potency is expected to aid in the nomination of pharmaceuticals, dietary supplements, environmental pollutants, and occupational and other chemicals for in-depth evaluation of the CYP3A4 inhibitory activity. It may serve also as an estimate of chemical interactions via CYP3A4 metabolic pharmacokinetic pathways occurring through polypharmacy and nutritional and environmental exposures to chemical mixtures

Weed suppression and tolerance in winter oats

A crops ability to both suppress weed growth and tolerate weed competition is a key consideration when taking an agroecological approach to weed management. Amongst other cereals, oats are widely considered to have superior weed competitiveness yet studies examining competitive ability between oat varieties are rare. We investigated the ability of oats to suppress weeds and yield in the presence of competition from weeds in trials involving five husked and three naked oat varieties at an organic site in the east of England over four trial years (2009-13). We identified a number of key traits that were important for weed suppression including establishment rates, tillering ability, and early Leaf Area Index (LAI) which highlight the importance of rapid early growth rates. Furthermore, taller varieties tended to be more weed tolerant but not necessarily more suppressive. Trade-offs between competitive traits and yield were not found in this study. Crop tillering ability was highlighted as an important trait for selection due to its beneficial effects on weed suppression as well as grain yield and also its high heritability

Discovery of anthelmintic drug targets and drugs using chokepoints in nematode metabolic pathways

Parasitic roundworm infections plague more than 2 billion people (1/3 of humanity) and cause drastic losses in crops and livestock. New anthelmintic drugs are urgently needed as new drug resistance and environmental concerns arise. A "chokepoint reaction" is defined as a reaction that either consumes a unique substrate or produces a unique product. A chokepoint analysis provides a systematic method of identifying novel potential drug targets. Chokepoint enzymes were identified in the genomes of 10 nematode species, and the intersection and union of all chokepoint enzymes were found. By studying and experimentally testing available compounds known to target proteins orthologous to nematode chokepoint proteins in public databases, this study uncovers features of chokepoints that make them successful drug targets. Chemogenomic screening was performed on drug-like compounds from public drug databases to find existing compounds that target homologs of nematode chokepoints. The compounds were prioritized based on chemical properties frequently found in successful drugs and were experimentally tested using Caenorhabditis elegans. Several drugs that are already known anthelmintic drugs and novel candidate targets were identified. Seven of the compounds were tested in Caenorhabditis elegans and three yielded a detrimental phenotype. One of these three drug-like compounds, Perhexiline, also yielded a deleterious effect in Haemonchus contortus and Onchocerca lienalis, two nematodes with divergent forms of parasitism. Perhexiline, known to affect the fatty acid oxidation pathway in mammals, caused a reduction in oxygen consumption rates in C. elegans and genome-wide gene expression profiles provided an additional confirmation of its mode of action. Computational modeling of Perhexiline and its target provided structural insights regarding its binding mode and specificity. Our lists of prioritized drug targets and drug-like compounds have potential to expedite the discovery of new anthelmintic drugs with broad-spectrum efficacy

Application of Serological Tools and Spatial Analysis to Investigate Malaria Transmission Dynamics in Highland Areas of Southwest Uganda.

Serological markers, combined with spatial analysis, offer a comparatively more sensitive means by which to measure and detect foci of malaria transmission in highland areas than traditional malariometric indicators. Plasmodium falciparum parasite prevalence, seroprevalence, and seroconversion rate to P. falciparum merozoite surface protein-119 (MSP-119) were measured in a cross-sectional survey to determine differences in transmission between altitudinal strata. Clusters of P. falciparum parasite prevalence and high antibody responses to MSP-119 were detected and compared. Results show that P. falciparum prevalence and seroprevalence generally decreased with increasing altitude. However, transmission was heterogeneous with hotspots of prevalence and/or seroprevalence detected in both highland and highland fringe altitudes, including a serological hotspot at 2,200 m. Results demonstrate that seroprevalence can be used as an additional tool to identify hotspots of malaria transmission that might be difficult to detect using traditional cross-sectional parasite surveys or through vector studies. Our study findings identify ways in which malaria prevention and control can be more effectively targeted in highland or low transmission areas via serological measures. These tools will become increasingly important for countries with an elimination agenda and/or where malaria transmission is becoming patchy and focal, but receptivity to malaria transmission remains high